History of IPF (Idiopathic Pulmonary Fibrosis)

In the absence of UIP pattern on HRCT a surgical lung biopsy is required for confident diagnosis.

Histologic specimens for the diagnosis of IPF must be taken at least in three different places and be large enough that the pathologist can comment on the underlying lung architecture.
Small biopsies, such as those obtained via transbronchial lung biopsy (performed during bronchoscopy) are usually not sufficient for this purpose.

Hence larger biopsies obtained surgically via a ‘Thoracotomy’ or ‘Thoracoscopy’ are usually necessary.
Lung tissue from people with IPF usually show a characteristic histopathologic UIP pattern and so is the pathologic counterpart of IPF.

Although a pathologic diagnosis of IPF, a UIP often corresponds to a clinical diagnosis of IPF, a UIP histological pattern can be seen in other diseases as well, and fibrosis of known origin (e.g. Rheumatic diseases).
There are four key features of UIP including interstitial fibrosis in a ‘patch work pattern’ interstitial scarring, honeycomb changes and fibroblast foci.

Fibroblastic foci are dense collections of fibroblasts and scar tissue and together with honeycombing, are the main pathological findings that allow a diagnosis of UIP.

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Important “Remedies” mostly used in IPF

IPF (Idiopathic Pulmonary Fibrosis) : Important remedies to get cure

Beryllium:

Beryllium is indicated for people where there is formation of granulomas/nodules those are formed in the lung and may appear in other bodily systems and organs. Beryllium has been found useful in the treatment of “Sarcoma” in Lung Cancer. It is indicated for cases when the individual has difficulty in breathing and lung pain made worse when it moves. There may be deep, dry cough and other respiratory diseases present, like Emphysema.

Silicea:

Silicea is indicated in cases of Fibroid development of the lung tissue is characteristic, wit thickening and scarring. The silicea patient is chilly, wanting to sit near the heater for warmth. Aversion to dratts, cold hands and feet, lack of appetite is seen in the patient. The remedy may helpful for relieving sharp pains in the lungs, hemorrhaging in the capillaries and coughing with thick phlegm.

Arsenicum Album :

> Better from heat, from head elevated warm drink.
> Worse, wet weather, after midnight from cold, cold drinks or food seashore right side.
> The patient is unable to lie down, he has fear of suffocation.
> The air passages are constricted in the midnight.
> In the Ars alb patient asthma is worse in midnight.
> There is burning in chest in this patient. Parkinson’s Disease(PD).
> Suffocative catarrh.
> Cough is worse after midnight, worse lying on back.
> The expectoration is scanty frothy in this patient.
> Darting pain through upper third of right lung.
> There is wheezing respiration in Are ulb patient.
> Haemoptysis with pain between shoulders is found in Ars alb patient.
> There is burning heat all over.
> Cough is dry, as from sulphur fumes, after drinking.

Causticum:

> Causticum patient feels better in Damp, wet weather warmth.
> Heat of bed is felt by the patient.
> Expectoration is day time only.
> Mucous expectoration found in afternoon.
> There is cutting pain in right side of nose.
> Running/blocked nose.
> Hoarseness with pain in the chest, aphonia.
> Cough with raw soreness of chest.
> Cough with pain in hip, especially left worse in evening.
> The patient can not lie down at night.
> Difficulty of voice of singers and public speakers.

Hepar Sulph:

> The patient loses voice and coughs when exposed to dry, cold wind,
> There is hoarseness, with loss of voice.
> Cough troublesome when walking cough is dry, hoarse.
> Cough excited whenever any part of the body gets cold or uncovered or from eating anything cold.
> Crop with loose, rattling cough, worse in morning.
> There is choking cough in Hepar Sulp patient.
> When there is suffocative attack, the patient has to rise up and bend head backwards.
> The patient is anxious, wheezing moist breathing.
> Asthma is worse in dry cold air, better in damp.
> There is palpitation of heart in Hepar Sulph patient.

Kreosotum:

> There is nosebleed during coryza.
> Offensive smell and discharge in this patient.
> Chronic catarrah of the old patient.
> The patient feels better by warmth in open air, after menstruation, cold, rest.
> Inflammation of mucous membranes of respiratory organ.

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